反应 #2178679

反应方程式

2-chloro-cyclohex-1-enecarbonitrile

K2CO3

mercapto-acetic acid ethyl ester

→

oil

收率 101.4%

3-Amino-4,5,6,7-tetrahydro-benzo[b]thiophene-2-carboxylic acid ethyl ester

收率 101.4%

溶剂

EtOH THF

反应条件

后处理

1. 1
   其他after which it was fitted with a reflux condenser under N2 atmosphere
2. 2
   过滤The mixture was filtered through a pad of diatomaceous earth, such as Celite®
3. 3
   洗涤rinsing thoroughly with MeOH (400 mL)
4. 4
   浓缩After concentration
5. 5
   其他the title compound was purified by FCC (60% ethyl acetate (EtOAc)/hexanes)

实验过程

A 250 mL flask was charged with 2-chloro-cyclohex-1-enecarbonitrile (3.0 g, 21 mmol) in a 6:1 mixture of EtOH/THF (42 mL), K2CO3 (2.9 g, 21 mmol), and mercapto-acetic acid ethyl ester (3.5 mL, 32 mmol), after which it was fitted with a reflux condenser under N2 atmosphere and heated to 90° C. for 24 h. The mixture was filtered through a pad of diatomaceous earth, such as Celite®, rinsing thoroughly with MeOH (400 mL). After concentration, the title compound was purified by FCC (60% ethyl acetate (EtOAc)/hexanes) to give an amber-colored oil (4.8 g). MS: 226.1. 1H NMR (400 MHz, CDCl3) δ ppm 5.35 (s, 2H), 2.71-2.64 (m, 2H), 2.36-2.26 (m, 2H), 1.87-1.77 (m, 4H), 1.33 (t, J=7.1 Hz, 3H).

来源