反应 #217562

反应方程式

benzyloxycarbonyl glycine

diisopropylethylamine

TBTU

acetic acid 4-(tert-butoxy-carbonylprop-2-ynylamino)-but-2-enyl ester

4-acetoxymethyl-5-aminooctahydrocyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester

→

title product

4-acetoxymethyl-5-(2-benzyloxycarbonylaminoacetylamino)octahydrocyclopenta[c]-pyrrole-2-carboxylic acid tert-butyl ester

溶剂

acetonitrile

反应条件

后处理

1. 1
   浓缩The mixture is concentrated under vacuum
2. 2
   其他yielding a residue
3. 3
   其他The residue is purified by flash column chromatography

实验过程

By sequentially following the procedures of Example 3, Parts B and C, and Example 1, Parts A and B, acetic acid 4-(tert-butoxy-carbonylprop-2-ynylamino)-but-2-enyl ester is converted to 4-acetoxymethyl-5-aminooctahydrocyclopenta[c]pyrrole-2-carboxylic acid tert-butyl ester. A solution of this material and benzyloxycarbonyl glycine in acetonitrile is treated sequentially with diisopropylethylamine and TBTU, and the resulting mixture is stirred at room temperature until the reaction is complete. The mixture is concentrated under vacuum yielding a residue. The residue is purified by flash column chromatography providing the title product.

来源