反应 #2171076

反应方程式

compound 11

7-methyl-9-oxoxanthene-1-carboxylic acid methyl ester

hydrazine

→

benzopyrano[4,3,2-de]phthalazine

反应条件

实验过程

Prepared from the compound 11 (R=H) and 1.5 equivalent of hydrazine to give benzopyrano[4,3,2-de]phthalazine according to General Procedure C. To as solution of 0.3 g of benzopyrano[4,3,2-de]phthalazine in 7.5 mL of concentrate sulfuric acid is dropwise added 2.0 mL of fuming sulfuric acid at 0° C. The mixture is stirred for 3 hours at 0° C. and poured into 100 mL of ice-cold water. The precipitation is collected by filtration, washed with water to give of a white solid product, mp>300° C. (dec.). 1H-NMR (400 MHz, DMSO-d6): 12.7 (s, 1H), 8.35 (s, 1H), 7.92-7.90 (m, 2H), 7.76-7.71 (m, 2H), 7.38 (d, 1H).

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