反应 #2171075

反应方程式

potassium hydroxide

diazomethane

diazomethane

9-Oxoxanthene-1-carboxylic acid

diazomethane

N-methyl-N-nitrosotoluene-p-sulphonamide

→

ester

收率 100.0%

9-oxoxanthene-1-carboxylic acid methyl ester

收率 100.0%

溶剂

methyl alcohol

methanol

反应条件

后处理

1. 1
   其他formed
2. 2
   其他Removal of the solvent

实验过程

Esterification of acid can be achieved by several conventional methods by those skilled in the art. These procedures include utilizing diazomethane or methyl alcohol catalyzed by mineral acids. For example, ethereal diazomethane solution can be prepared for N-methyl-N-nitrosotoluene-p-sulphonamide and potassium hydroxide from a water bath. 9-Oxoxanthene-1-carboxylic acid (1.29 g, 5 mmol) in absolute methanol is added to this ethereal diazomethane solution at 0° C. until a pale yellow color formed. Removal of the solvent provides the desired ester solid in 100% yield. Thus the final products, Examples 5-9, can be prepared by condensation hydrazine with the ketonester 11 as described in General procedure C.

来源