反应 #2171068

反应方程式

phenyl 3-(2-phenyloxyphenyl)propionate

NaOH

HCl

→

3-(2-phenyloxyphenyl)propionic acid

溶剂

MeOH

反应条件

后处理

1. 1
   萃取extracted with EtOAc (100 ml)
2. 2
   洗涤The organic phase was washed with brine
3. 3
   干燥dried over sodium sulfate
4. 4
   浓缩concentrated in vacuo

实验过程

A mixture of phenyl 3-(2-phenyloxyphenyl)propionate (0.45 g, 1.30 mmol), 2N NaOH (20 ml) and MeOH (10 ml) was stirred at room temperature overnight, which was then neutralized to pH˜2 with concentrated HCl and extracted with EtOAc (100 ml). The organic phase was washed with brine and dried over sodium sulfate and concentrated in vacuo to yield 3-(2-phenyloxyphenyl)propionic acid as an oil. This was used for next step without further purification.

来源