反应 #2171064

反应方程式

ethyl acetate

sulfuric acid

3-(N′-(4-t-butyldimethylsilyloxymethylphenyl)ureido)-1-(2,2-diethoxyethyl)-3-((4-methylphenyl)aminocarbonylmethyl) indolin-2-one

Water

→

title compound

收率 88.0%

1-(2,2-diethoxyethyl)-3-(N′-(4-hydroxymethylphenyl)ureido)-3-((4-methylphenyl)aminocarbonylmethyl)indolin-2-one

收率 88.0%

溶剂

ethanol

反应条件

后处理

1. 1
   干燥the organic layer was dried with anhydrous sodium hydrogensulfate
2. 2
   workup.DISTILLATIONthe solvent was distilled off
3. 3
   其他The reaction mixture was purified by silica gel column chromatography

实验过程

3-(N′-(4-t-butyldimethylsilyloxymethylphenyl)ureido)-1-(2,2-diethoxyethyl)-3-((4-methylphenyl)aminocarbonylmethyl) indolin-2-one (308 mg) was dissolved in ethanol (15 mL), concentrated sulfuric acid (10 mg) was added, and the mixture was stirred at 15-30° C. for one hour. Water was added to the reaction solution, extraction was performed with ethyl acetate, the organic layer was dried with anhydrous sodium hydrogensulfate and the solvent was distilled off. The reaction mixture was purified by silica gel column chromatography to obtain 225 mg of the title compound (yield: 88%).

来源