反应 #2171063

ord-d4b06214f73641ed8e8dba32a4dc8f34

反应方程式

COC(=O)c1cccc(C(O)=CC(=O)c2cn(S(=O)(=O)c3ccccc3)c3ccc(Cl)cc23)c1
1-(1-benzenesulfonyl-5-chloroindol-3-yl)-3-(3-methoxycarbonylphenyl)-3-hydroxy-propen-1-one
[Li+].[OH-]
lithium hydroxide
→
O=C(O)c1cccc(C(O)=CC(=O)c2c[nH]c3ccc(Cl)cc23)c1
titled compound
O=C(O)c1cccc(C(O)=CC(=O)c2c[nH]c3ccc(Cl)cc23)c1
1-(5-Chloroindol-3-yl)-3-(3-carboxyphenyl)-3-hydroxy-propen-1-one

反应物

—
carboxylic acid
COC(=O)c1cccc(C(O)=CC(=O)c2cn(S(=O)(=O)c3ccccc3)c3ccc(Cl)cc23)c1
1-(1-benzenesulfonyl-5-chloroindol-3-yl)-3-(3-methoxycarbonylphenyl)-3-hydroxy-propen-1-one
[Li+].[OH-]
lithium hydroxide

试剂

无

溶剂

CO
methanol

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

The carboxylic acid in Example 100 was esterified to 1-(1-benzenesulfonyl-5-chloroindol-3-yl)-3-(3-methoxycarbonylphenyl)-3-hydroxy-propen-1-one. The compound was hydrolyzed with lithium hydroxide in methanol to give the titled compound.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06716605B2uspto-grants-2004_04