反应 #2171062

ord-a4fa492dc7d34a61bf59996e31b1fbf3

反应方程式

CC(=O)c1cn(S(=O)(=O)c2ccccc2)c2ccc(Cl)cc12
3-acetyl-1-benzenesulfonyl-5-chloroindole
COC(=O)c1cccc(C(=O)Cl)c1
3-methoxycarbonyl benzoylchloride
Cl
hydrochloric acid
→
O=C(O)c1cccc(C(O)=CC(=O)c2cn(S(=O)(=O)c3ccccc3)c3ccc(Cl)cc23)c1
titled compound
O=C(O)c1cccc(C(O)=CC(=O)c2cn(S(=O)(=O)c3ccccc3)c3ccc(Cl)cc23)c1
1-(1-Benzenesulfonyl-5-chloroindol-3-yl)-3-(3-carboxyphenyl)-3-hydroxy-propen-1-one

反应物

CC(=O)c1cn(S(=O)(=O)c2ccccc2)c2ccc(Cl)cc12
3-acetyl-1-benzenesulfonyl-5-chloroindole
COC(=O)c1cccc(C(=O)Cl)c1
3-methoxycarbonyl benzoylchloride
Cl
hydrochloric acid

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

In accordance with Example 99, 3-acetyl-1-benzenesulfonyl-5-chloroindole reacted with 3-methoxycarbonyl benzoylchloride, followed by hydrolysis with hydrochloric acid to give the titled compound.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06716605B2uspto-grants-2004_04