反应 #2171054

反应方程式

4-[5-chloro-1-(4-methoxycarbonylbenzyl)indol-3-yl-]2-hydroxy-4-oxo-2-butenoic acid

LiOH

→

titled compound

收率 79.0%

4-[1-(4-Carboxybenzyl)-5-chloroindol-3-yl]-2-hydroxy-4-oxo-2-butenoic acid

收率 79.0%

溶剂

MeOH

反应条件

后处理

1. 1
   其他the solvent was removed under reduced pressure
2. 2
   萃取the mixture was extracted with ethyl acetate
3. 3
   洗涤The organic layer was washed with water and saturated brine
4. 4
   其他dried
5. 5
   其他The solvent was evaporated
6. 6
   其他the residue was recrystallized from ethyl acetate/ether

实验过程

To a solution of 82 mg (0.2 mmol) of 4-[5-chloro-1-(4-methoxycarbonylbenzyl)indol-3-yl-]2-hydroxy-4-oxo-2-butenoic acid, prepared in a manner similar to that described in Example 23, in 75% MeOH (35 ml) was added 42 mg (1.0 mmol) of LiOH. After the mixture was stirred for 5 hours at room temperature, the solvent was removed under reduced pressure. The residue was acidified with 1 N hydrochloric acid and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, and then dried. The solvent was evaporated and the residue was recrystallized from ethyl acetate/ether to give 63 mg of the titled compound. Yield: 79%.

来源