反应 #2171051

ord-4e2465c160c2486f97a54a7b5585b8d1

反应方程式

Cc1cc2cc(Cl)ccc2n1S(=O)(=O)c1ccccc1
1-Benzenesulfonyl-5-chloro-2-methylindole
CC(=O)OC(C)=O.[Al+3].[Cl-].[Cl-].[Cl-]
Ac2O AlCl3
→
CC(=O)c1c(C)n(S(=O)(=O)c2ccccc2)c2ccc(Cl)cc12
3-acetyl-1-benzenesulfonyl-5-chloro-2-methylindole
收率 86.0%

反应物

Cc1cc2cc(Cl)ccc2n1S(=O)(=O)c1ccccc1
1-Benzenesulfonyl-5-chloro-2-methylindole
CC(=O)OC(C)=O.[Al+3].[Cl-].[Cl-].[Cl-]
Ac2O AlCl3
—
example 2 ( 3 )

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

1-Benzenesulfonyl-5-chloro-2-methylindole prepared in accordance with the literature (J. Org. Chem., 47, 757 (1982) was reacted with Ac2O/AlCl3 in a similar manner described in Reference example 2 (3) to give 3-acetyl-1-benzenesulfonyl-5-chloro-2-methylindole. Yield: 86%.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US06716605B2uspto-grants-2004_04