反应 #2171048

反应方程式

diisopropyl azodicarboxylate

3-acetyl-5-chloroindole

triphenylphosphine

phenethyl alcohol

→

titled compound

收率 65.0%

3-Acetyl-5-chloro-1-phenethylindole

收率 65.0%

溶剂

THF

反应条件

后处理

1. 1
   workup.ADDITIONwas added under ice-
2. 2
   温度cooling
3. 3
   浓缩the mixture was concentrated under reduced pressure
4. 4
   其他The obtained residue was chromatographed on silica gel (¼ ethyl acetate/toluene as eluant)

实验过程

To a mixture of 0.58 g (3 mmol) of 3-acetyl-5-chloroindole, 1.42 g (5.4 mmol) of triphenylphosphine and 0.66 g (5.4 mmol) of phenethyl alcohol in THF (12 ml) was added under ice-cooling, 1.09 g (5.4 mmol) of diisopropyl azodicarboxylate. After stirring for 3 hours at room temperature, the mixture was concentrated under reduced pressure. The obtained residue was chromatographed on silica gel (¼ ethyl acetate/toluene as eluant) to give 0.58 g of the titled compound as an oil. Yield: 65%.

来源