反应 #2171035

反应方程式

2,6-difluoroaniline

bromine

→

4-bromo-2,6-difluoroaniline

收率 91.7%

溶剂

acetic acid

acetic acid

反应条件

后处理

1. 1
   过滤the precipitated crystals are filtered off with suction
2. 2
   洗涤washed a number of times with a total of 3000 ml of ice-water
3. 3
   其他the crystals are dried over Al2O3 under reduced pressure

实验过程

507.5 g of 2,6-difluoroaniline are added to 2500 ml of acetic acid, the mixture is cooled to 10° C., and a solution of 195 ml of bromine in 250 ml of acetic acid is added dropwise at 10-15° C. over the course of 3 hours. The mixture is subsequently stirred at room temperature for a further 1 hour and poured into 5000 ml of ice-water, the precipitated crystals are filtered off with suction and washed a number of times with a total of 3000 ml of ice-water, and the crystals are dried over Al2O3 under reduced pressure, giving 4-bromo-2,6-difluoroaniline, yield 91.7%, GC 99.6%.

来源