反应 #217033

反应方程式

4,6-dibromotryptophan ethyl ester

triethylamine

benzyl chloroformate

→

title compound

N-(Benzyloxycarbonyl)-4,6-dibromotryptophan ethyl ester

溶剂

methylene chloride

methylene chloride

反应条件

后处理

1. 1
   洗涤wash with 1M hydrochloric acid (100 mL) and brine (100 mL)
2. 2
   干燥Dry (MgSO4)
3. 3
   其他evaporate the solvent in vacuo
4. 4
   其他purify by silica gel chromatography

实验过程

Mix DL-4,6-dibromotryptophan ethyl ester (1.20 g, 3.07 mmol), triethylamine (341 mg, 3.38 mmol) and methylene chloride (50 mL). Add benzyl chloroformate (692 mg, 4.06 mmol) and stir for 12 hours. Dilute with methylene chloride, wash with 1M hydrochloric acid (100 mL) and brine (100 mL). Dry (MgSO4) and evaporate the solvent in vacuo and purify by silica gel chromatography to give the title compound.

来源