反应 #2160

反应方程式

3-(4-chlorobenzoyl)propionic acid

hydrazine monohydrate

→

6-(4-chlorophenyl)-4,5-dihydropyridazinone

收率 81.5%

溶剂

ethanol

反应条件

后处理

1. 1
   其他A thick solid was formed which
2. 2
   workup.DISSOLUTIONdissolved
3. 3
   温度after heating
4. 4
   温度The resulting solution was refluxed for 3 h
5. 5
   温度cooled
6. 6
   其他the solid formed
7. 7
   过滤filtered
8. 8
   其他dried

实验过程

To a solution of 3-(4-chlorobenzoyl)propionic acid (20 g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.

来源