反应 #215285

反应方程式

3-benzoyloxy-6,7-dimethoxy-1,2,3,4-tetrahydrocarbazole

sodium hydride

ethyl bromoacetate

→

3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole

溶剂

dimethylformamide

反应条件

后处理

1. 1
   其他The 3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole was prepared
2. 2
   过滤The crude product in ethyl acetate was filtered through alumina
3. 3
   其他the filtrate was evaporated to dryness under reduced pressure
4. 4
   其他the residue was recrystallized from ethyl acetate

实验过程

The 3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole was prepared by following an alkylation procedure similar to that described in Example 11 but using 17.6 g. of 3-benzoyloxy-6,7-dimethoxy-1,2,3,4-tetrahydrocarbazole (see Example 4) and 2.14 g. of sodium hydride (56% in mineral oil) in 200 ml. of dimethylformamide, and 8.4 g. of ethyl bromoacetate. The crude product in ethyl acetate was filtered through alumina, the filtrate was evaporated to dryness under reduced pressure and the residue was recrystallized from ethyl acetate to give 3-benzoyloxy-6,7-dimethoxy-9-carbethoxymethyl-1,2,3,4-tetrahydrocarbazole, m.p. 125°-127° C.

来源