反应 #215143

反应方程式

water

3-sulfamoyl-4-chlorobenzoyl chloride

1-cyclohexyl-1-phenyl hydrazine

sodium bicarbonate

→

1-Cyclohexyl-1-phenyl-2-(3-sulfamoyl-4-chlorobenzoyl)-hydrazine

溶剂

isopropanol

反应条件

后处理

1. 1
   温度chilled
2. 2
   workup.STIRRINGThe mixture was stirred for 2 hours at room temperature and for 2.5 hours at 40°-50° C
3. 3
   其他was recrystallized from aqueous ethanol

实验过程

A mixture of 8.5 g (0.045 mol) 1-cyclohexyl-1-phenyl hydrazine in 50 ml isopropanol and 4.7 g (0.045 mol) sodium bicarbonate was stirred and chilled. Addition of 11.36 g (0.045 mol) 3-sulfamoyl-4-chlorobenzoyl chloride was made in several portions. The mixture was stirred for 2 hours at room temperature and for 2.5 hours at 40°-50° C. Dilution of the reaction mixture with water yielded a solid material which was recrystallized from aqueous ethanol. M.P. 216°-217° C.

来源