反应 #214841

反应方程式

butylmercaptan

sodium hydride

1-[2-chloro-2-(2,4-dichlorophenyl)-ethyl]-1,2,4-triazole

→

1-[2-n-butylmercapto-2-(2,4-dichlorophenyl)-ethyl]-1,2,4-triazole

溶剂

tetrahydrofuran

tetrahydrofuran

反应条件

后处理

1. 1
   浓缩The mixture is concentrated
2. 2
   workup.STIRRINGstirred with water
3. 3
   萃取extracted with dichloromethane
4. 4
   干燥The resulting dichloromethane solution is dried
5. 5
   其他evaporated

实验过程

12.55 parts by weight of butylmercaptan is dripped into a suspension of 3.33 parts by weight of sodium hydride in 180 parts by weight of tetrahydrofuran. A solution of 27.5 parts by weight of 1-[2-chloro-2-(2,4-dichlorophenyl)-ethyl]-1,2,4-triazole in 50 parts of tetrahydrofuran is then dripped in and the mixture is stirred for 3 days at room temperature. The mixture is concentrated, stirred with water, and extracted with dichloromethane. The resulting dichloromethane solution is dried and evaporated. There is obtained 29.5 parts of crude 1-[2-n-butylmercapto-2-(2,4-dichlorophenyl)-ethyl]-1,2,4-triazole, which is dissolved in ethyl acetate. When hydrogen chloride is passed into the ethyl acetate solution, 25.9 parts of 1-[2-n-butylmercapto-2-(2,4-dichlorophenyl)-ethyl]-1,2,4-triazole hydrochloride, m.p. 143° C., precipitates out.

来源