反应 #2145377

反应方程式

2,4-dichlorophenol

1-bromo-3-methoxy-3-methyl-2-butanone

potassium carbonate

→

1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone

收率 85.7%

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux temperature for 30 minutes
3. 3
   温度The reaction mixture was cooled
4. 4
   过滤filtered
5. 5
   其他the solvent evaporated from the filtrate
6. 6
   其他separated as a white crystalline solid

实验过程

A stirred mixture of 13.04 g (0.08 mole) of 2,4-dichlorophenol, 15.61 g (0.08 mole) 1-bromo-3-methoxy-3-methyl-2-butanone, and 11.1 g (0.08 mole) powdered potassium carbonate in 300 ml acetonitrile was heated at reflux temperature for 30 minutes. The reaction mixture was cooled, filtered, and the solvent evaporated from the filtrate. The residual oil was taken up in hexane and cooled to -20° C., whereupon the product separated as a white crystalline solid. There was thus obtained 19 g (85.7% yield) of 1-(2,4-dichlorophenoxy)-3-methoxy-3-methyl-2-butanone, m.p. 45.5°-47.5° C.

来源