反应 #214454

反应方程式

glutaric anhydride

4-aminopyridine

→

1-(4-pyridyl)-piperidine-2,6-dione

溶剂

xylene

反应条件

后处理

1. 1
   其他The starting material is prepared
2. 2
   温度is refluxed
3. 3
   过滤the solids are filtered off
4. 4
   萃取extracted twice with 200 ml chloroform
5. 5
   温度at reflux
6. 6
   其他The combined extracts are evaporated
7. 7
   其他the residue recrystallized twice from ethyl acetate

实验过程

The starting material is prepared as follows: The mixture of 34.2 g of glutaric anhydride, 28.2 g of 4-aminopyridine and 650 ml of xylene is refluxed with stirring for 6 hours. It is allowed to cool to room temperature, the solids are filtered off and extracted twice with 200 ml chloroform at reflux. The combined extracts are evaporated and the residue recrystallized twice from ethyl acetate to yield the 1-(4-pyridyl)-piperidine-2,6-dione melting at 153°-155°.

来源