反应 #214375

反应方程式

6-methoxypyridine-3-carboxaldehyde

monoethyl malonate

→

ethyl 3-(6-methoxy-3-pyridyl)acrylate

收率 79.2%

溶剂

pyridine

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度under reflux for 5 hours
3. 3
   其他was evaporated to an oil
4. 4
   其他This oil was partitioned between ether and dilute aqueous ammonia
5. 5
   洗涤The ether layer was washed with water
6. 6
   其他evaporated to an oil which
7. 7
   其他crystallised

实验过程

A mixture of 6-methoxypyridine-3-carboxaldehyde (2.34 g), monoethyl malonate (4.51 g), pyridine (12 ml) and piperidine (6 drops) was heated under reflux for 5 hours and was evaporated to an oil. This oil was partitioned between ether and dilute aqueous ammonia. The ether layer was washed with water and evaporated to an oil which crystallised on standing to give ethyl 3-(6-methoxy-3-pyridyl)acrylate (2.8 g, 79%), m.p. 49-52°.

来源