反应 #2139952

反应方程式

4-bromo-2-fluorophenol

ethyl bromide

potassium carbonate

→

4-bromo-1-ethoxy-2-fluorobenzene

收率 99.3%

溶剂

ethyl methyl ketone

反应条件

后处理

1. 1
   过滤The solution was subsequently filtered
2. 2
   其他the filtrate was evaporated
3. 3
   过滤the crude product was filtered through silica gel with n-hexane

实验过程

100 g (0.524 mol) of 4-bromo-2-fluorophenol and 66.7 g (0.612 mol) of ethyl bromide were dissolved in 2 1 of ethyl methyl ketone and refluxed for 24 hours in the presence of 185 g (1.34 mol) of potassium carbonate. The solution was subsequently filtered, the filtrate was evaporated, and the crude product was filtered through silica gel with n-hexane, giving 114 g (99% of theory) of 4-bromo-1-ethoxy-2-fluorobenzene as a colourless liquid.

来源