反应 #2139949

反应方程式

water

ethyldiisopropylamine

6-bromo-3-butoxy-2-fluorophenol

2-methoxyethoxymethyl chloride

→

1-bromo-4-butoxy-3-fluoro-2-(2-methoxyethoxymethoxy)benzene

收率 99.8%

溶剂

dichloromethane

反应条件

后处理

1. 1
   workup.WAITthe mixture was left
2. 2
   萃取extracted with dichloromethane
3. 3
   其他evaporated
4. 4
   过滤the crude product was filtered through silica gel with n-heptane/MTB ether (3:1)

实验过程

60.4 ml (0.355 mol) of ethyldiisopropylamine were added with ice-cooling to 77.4 g (0.294 mol) of 6-bromo-3-butoxy-2-fluorophenol dissolved in 500 ml of dichloromethane, 40.3 ml (0.355 mol) of 2-methoxyethoxymethyl chloride were added dropwise, and the mixture was left to stirr overnight at room temperature. The batch was hydrolysed using water, extracted with dichloromethane and evaporated, and the crude product was filtered through silica gel with n-heptane/MTB ether (3:1), giving 103 g (99%) of 1-bromo-4-butoxy-3-fluoro-2-(2-methoxyethoxymethoxy)benzene as a yellow oil.

来源