反应 #2139948

反应方程式

trans-6-bromo-2-fluoro-3-(4-pentylcyclohexyl)-benzoic acid

potassium carbonate

methyl iodide

→

methyl 6-bromo-2-fluoro-3-(4-pentylcyclohexyl)benzoate

收率 101.6%

溶剂

acetone

反应条件

后处理

1. 1
   温度the mixture was refluxed overnight
2. 2
   过滤The batch was filtered
3. 3
   workup.DISTILLATIONthe solvent was distilled off

实验过程

17.1 g (46.0 mmol) of trans-6-bromo-2-fluoro-3-(4-pentylcyclohexyl)-benzoic acid were dissolved in 70 ml of acetone, 7.66 g (55.4 mmol) of potassium carbonate and 3.14 ml (50.6 mmol) of methyl iodide were added, and the mixture was refluxed overnight. The batch was filtered, and the solvent was distilled off, giving 18 g (100%) of methyl 6-bromo-2-fluoro-3-(4-pentylcyclohexyl)benzoate as a colourless oil, which was reacted further without further purification.

来源