反应 #2139940

反应方程式

triethylamine

N-hydroxy-5-norbornene-2,3-dicarboximide

2-chloroethanesulfonyl chloride

triethylamine

cyclohexanethiol

→

product

收率 79.7%

N-(2-cyclohexylsulfanyl-ethanesulfonyloxy)-5-norbornene-2,3-dicarboximide

收率 79.7%

溶剂

water

THF

反应条件

后处理

1. 1
   温度while cooling over an ice-bath
2. 2
   workup.ADDITIONis added first
3. 3
   萃取extracted two times with ethyl acetate (300 ml)
4. 4
   洗涤The combined organic phases are washed with water (300 ml)
5. 5
   干燥dried over MgSO4
6. 6
   浓缩concentrated
7. 7
   其他The residue is purified by flash chromatography on silica gel with hexane and ethyl acetate (7:3) as eluent

实验过程

A solution of 5.38 g (30.0 mmol) of N-hydroxy-5-norbornene-2,3-dicarboximide in THF (75 ml) is treated successively with 2-chloroethanesulfonyl chloride (3.47 ml, 33.0 mmol) and triethylamine (9.6 ml, 69.0 mmol) while cooling over an ice-bath. After stirring for 1 h at 0° C. triethylamine (6.3 ml, 45.0 mmol) is added first, followed by the addition of cyclohexanethiol (4.05 ml, 33.0 mmol). The beige suspension is further stirred for 1 h at room temperature, then poured into water (140 ml) and extracted two times with ethyl acetate (300 ml). The combined organic phases are washed with water (300 ml), dried over MgSO4, and concentrated. The residue is purified by flash chromatography on silica gel with hexane and ethyl acetate (7:3) as eluent, yielding 9.22 g of the product as a white solid. The, structure is confirmed by the 1H-NMR spectrum (CDCl3). δ [ppm]: 1.21-1.40 (m, 6H), 1.50-1.56 (m, 1H), 1.58-1.67 (m, 1H), 1.74-1.85 (m, 3H), 1.92-2.04 (m, 2H), 2.67-2.79 (m, 1H), 3.03-3.11 (m, 2H), 3.34 (s, 2H), 3.48 (s, 2H), 3.62-3.70 (m, 2H), 6.19 (s, 2H). mp. 96-98° C.

来源