反应 #2126727

反应方程式

pyridine

benzo[1,3]dioxol-5-yl-acetyl chloride

2-amino-4,6-difluoro-benzoic acid

→

title compound

收率 80.0%

2-(2-benzo[1,3]dioxol-5-yl-acetylamino)-4,6-difluoro-benzoic acid

收率 80.0%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他The solvent was evaporated
2. 2
   workup.ADDITIONthe residue was diluted with 2 N HCl solution
3. 3
   其他the precipitation of a brown solid which
4. 4
   过滤was filtered
5. 5
   洗涤washed with water
6. 6
   其他dried under vacuum at 50° C.

实验过程

To a solution of commercially available benzo[1,3]dioxol-5-yl-acetyl chloride (3.70 g, 18.70 mmol) in anhydrous dichloromethane (20 mL) was added 2-amino-4,6-difluoro-benzoic acid (2.20 g, 12.5 mmol). After the addition of pyridine (5 mL), the mixture was heated under microwave condition at 120° C. for 5 minutes. The solvent was evaporated and the residue was diluted with 2 N HCl solution to induce the precipitation of a brown solid which was filtered, washed with water and dried under vacuum at 50° C., to afford the title compound (3.34 g, 80% yield).

来源