反应 #2122516

反应方程式

Piperidine

Compound 8

2-methylbenzoxazole-6-sulfonyl chloride

→

Compound 9

收率 98.5%

N-(2-methylbenzoxazole-6-sulfonyl)piperidine

收率 98.5%

溶剂

chloroform

DMF

反应条件

后处理

1. 1
   洗涤washed with water (2×, 50 ml) and brine (1×, 50 ml)
2. 2
   干燥The organic layer was then dried over sodium sulfate
3. 3
   其他evaporated

实验过程

Piperidine (2.2 g, 26 mmol) was added drop wise to a solution of Compound 8 (3.0 g, 10 mmol) in chloroform (30 ml) and DMF (10 ml). The combined mixture was stirred at room temperature for 1 hour, and then washed with water (2×, 50 ml) and brine (1×, 50 ml). The organic layer was then dried over sodium sulfate and evaporated to provide 2.76 g (76%) of Compound 9 as a sticky white solid. TLC analysis showed Rf=0.25 (30% ethyl acetate in hexane). The structure of this compound is given below:

来源