反应 #2122490

反应方程式

1-Methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid

1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid

thionyl chloride

→

1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carbonyl chloride

溶剂

toluene

反应条件

后处理

1. 1
   其他The solvent was evaporated

实验过程

700 mg 1-Methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carboxylic acid (from Step 5) was dissolved in 10 ml toluene, 1 drop N,N-dimethylformamide was added, followed by 400 mg thionyl chloride. The mixture was heated to 100° C. for 1 hour, at which time the evolution of gas has ceased. The solvent was evaporated, to yield crude 1-methoxy-4-(4-methoxy-benzylsulfanyl)-piperidine-4-carbonyl chloride.

来源