反应 #2116

反应方程式

benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate

ammonia

→

Monoethyl ammonium [4-(7-ethoxymethyl-3-methylxanthin-1-yl)butyl]-phosphonate

溶剂

ethanol

反应条件

后处理

1. 1
   过滤The catalyst was filtered off
2. 2
   浓缩the filtrate was concentrated under reduced pressure
3. 3
   其他the solution obtained
4. 4
   其他after evaporating the solvent
5. 5
   其他was then crystallized from diisopropyl ether

实验过程

6.3 g (0.013 mol) of benzylethyl 4-(7-ethoxymethyl-3-methylxanthin-1-yl)-butylphosphonate were hydrogenated in 100 ml of ethanol over 0.5 g of palladium (10%) on active carbon at room temperature in the course of 4 hours. The catalyst was filtered off, the filtrate was concentrated under reduced pressure, the solution obtained was treated with methanolic ammonia and the residue which remained after evaporating the solvent was then crystallized from diisopropyl ether.

来源