反应 #2109

反应方程式

diethyl 5-hydroxypentylphosphonate

3,4-dihydropyran

pyridinium toluene-4-sulfonate

→

Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

溶剂

dichloromethane

反应条件

后处理

1. 1
   温度under reflux for 16 hours
2. 2
   洗涤The solution was washed with water and saturated sodium hydrogen carbonate solution
3. 3
   干燥dried over sodium sulfate
4. 4
   workup.DISTILLATIONdistilled in a bulb tube

实验过程

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

来源