反应 #2075717

反应方程式

Sodium borohydride

1-(5-bromo-2-chlorophenyl)ethanone

→

title compound

收率 99.3%

1-(5-Bromo-2-chlorophenyl)-ethanol

收率 99.3%

溶剂

methanol

反应条件

后处理

1. 1
   其他The resulting bubbling white mixture
2. 2
   其他The reaction mixture was quenched with acetone (50 mL)
3. 3
   浓缩concentrated by rotary evaporation
4. 4
   其他The residue was partitioned between ethyl acetate and water
5. 5
   其他The organic phase was dried
6. 6
   浓缩concentrated

实验过程

Sodium borohydride (1.182 g, 51.4 mmol) was added to a stirred solution of 1-(5-bromo-2-chlorophenyl)ethanone (10 g, 42.8 mmol) in methanol at 0° C., The resulting bubbling white mixture was allowed to warm to room temperature and stirred for 2 h. The reaction mixture was quenched with acetone (50 mL) and concentrated by rotary evaporation. The residue was partitioned between ethyl acetate and water. The organic phase was dried and concentrated to yield the title compound (10 g, 42.5 mmol, 99% yield) as a white solid: 1H NMR (CDCl3): δ 7.75 (d, 1H), 7.32 (m, 1H), 7.19 (m, 1H), 5.23 (q, 1H), 1.95 (d, 1H), 1.48 (d, 3H).

来源