反应 #2075694

反应方程式

carbon tetrabromide

tert-butyl [(3-hydroxypropyl)-trifluoroacetylamino]acetate

triphenylphosphine

→

tert-butyl[(3-bromopropyl)trifluoro-acetylamino]acetate

溶剂

tetrahydrofuran

acetonitrile

反应条件

后处理

1. 1
   其他at 15-20° C
2. 2
   workup.ADDITIONwere added dropwise

实验过程

10 g of tert-butyl [(3-hydroxypropyl)-trifluoroacetylamino]acetate (35 mmol) were solubilized in 150 ml of tetrahydrofuran. 12.4 g of triphenylphosphine (47.3 mmol) were added and the reaction mixture was thermostated at 15-20° C. 15.1 g of carbon tetrabromide (45.6 mmol), dissolved in 60 ml of acetonitrile, were added dropwise using a dropping funnel and the whole was stirred at room temperature for 4 hours.

来源