反应 #2069945

反应方程式

sodium hydrogencarbonate

Methanesulfonyl chloride

triethylamine

o-iodobenzyl alcohol

→

title compound

收率 100.7%

1-(Chloromethyl)-2-iodobenzene

收率 100.7%

溶剂

methylene chloride

反应条件

后处理

1. 1
   萃取the resulting mixture was extracted with methylene chloride
2. 2
   干燥The methylene chloride layer was dried over anhydrous magnesium sulfate
3. 3
   浓缩concentrated under reduced pressure

实验过程

Methanesulfonyl chloride (2.0 ml, 29 mmol) and triethylamine (3.6 ml, 26 mmol) were added to a solution of o-iodobenzyl alcohol (5.0 g, 21 mmol) in methylene chloride (50 ml) cooled to 0° C., and the mixture was stirred at that temperature for 19 hours. A 5% aqueous sodium hydrogencarbonate solution was added, and the resulting mixture was extracted with methylene chloride. The methylene chloride layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give the title compound (5.34 g).

来源