反应 #2069943

反应方程式

compound

(4-Butylphenyl)(1-isoquinolyl)ketone

hydrazine monohydrate

potassium hydroxide

→

title compound

收率 55.3%

1-(4-butylbenzyl)isoquinoline

收率 55.3%

溶剂

diethylene glycol

反应条件

后处理

1. 1
   workup.WAITat 200° C. for 1 hour
2. 2
   温度The mixture was cooled to room temperature
3. 3
   萃取this was extracted with ethyl acetate
4. 4
   洗涤The extract was washed with water
5. 5
   干燥dried over anhydrous magnesium sulfate
6. 6
   浓缩concentrated under reduced pressure
7. 7
   其他The residue was purified by silica gel column chromatography

实验过程

The compound of Example B3 (1.7 g, 6.0 mmol), hydrazine monohydrate (836 mg, 17 mmol), and potassium hydroxide (769 mg, 14 mmol) were added to diethylene glycol (8.5 ml), and this mixture was stirred at 80° C. for 1 hour, at 160° C. for 3.5 hours, then at 200° C. for 1 hour. The mixture was cooled to room temperature, ice water was added, and this was extracted with ethyl acetate. The extract was washed with water, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (914 mg).

来源