反应 #2069939

反应方程式

3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester

TFA DCM

→

title compound

收率 101.6%

3-(2-Naphthalen-2-yl-propionylamino)-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-1-carboxylic acid ethyl ester

收率 101.6%

溶剂

DCM

反应条件

后处理

1. 1
   其他evaporated to dryness
2. 2
   workup.DISSOLUTIONThe resulting residue was dissolved in DCM
3. 3
   洗涤the solution was washed with brine
4. 4
   workup.ADDITIONtreated with NaHCO3 aq. The obtained precipitate
5. 5
   过滤was filtered
6. 6
   洗涤washed with water and DCM
7. 7
   其他dried under vacuum

实验过程

2.5 g (5.2 mmol) of 3-(2-naphthalen-2-yl-propionylamino)-4,6-dihydro-pyrrolo[3,4-c]pyrazole-1,5-dicarboxylic acid 5-tert-butyl ester 1-ethyl ester in 15 ml DCM was treated with 16 ml of (1:1) TFA/DCM. The reaction mixture was stirred for 30 min. and evaporated to dryness. The resulting residue was dissolved in DCM and the solution was washed with brine and then treated with NaHCO3 aq. The obtained precipitate was filtered, washed with water and DCM, and then dried under vacuum to give 2.0 g (quantitative yield) of the title compound.

来源