反应 #2069929

反应方程式

4-cyano-4′-hydroxybiphenyl

allyl bromide

potassium carbonate

2-butanone

→

4-allyloxy-4′-cyanobiphenyl

收率 91.3%

溶剂

Water

反应条件

后处理

1. 1
   其他A solution prepared
2. 2
   温度was refluxed for 7 hours
3. 3
   洗涤the organic layer was washed with water
4. 4
   干燥dried with anhydrous magnesium sulfate
5. 5
   其他The solvent was evaporated away
6. 6
   其他the resulting residue was purified through silica gel column chromatography
7. 7
   其他further recrystallized from ethanol

实验过程

A solution prepared by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of allyl bromide and 25 g of potassium carbonate to 250 ml of 2-butanone was refluxed for 7 hours. Water was added to the reaction solution for liquid-liquid separation, and the organic layer was washed with water and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel column chromatography using toluene as an eluent solvent and then further recrystallized from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

来源