反应 #2063060

反应方程式

1-(3,4-dichlorophenyl)piperazine

5-chloropentanenitrile

sodium carbonate

→

4-(3,4-dichlorophenyl)-1-piperazinepentanenitrile

收率 72.1%

溶剂

4-methyl-2-pentanone

反应条件

后处理

1. 1
   温度refluxed for 10 hours
2. 2
   温度The reaction mixture was cooled
3. 3
   过滤filtered
4. 4
   其他the filtrate was evaporated
5. 5
   其他The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 95/5)
6. 6
   其他The pure fractions were collected
7. 7
   其他the solvent was evaporated

实验过程

A mixture of 1-(3,4-dichlorophenyl)piperazine (0.1 mol), 5-chloropentanenitrile (0.13 mol), sodium carbonate (10 g) and potassium iodide (0.1 g) in 4-methyl-2-pentanone (280 ml) was stirred and refluxed for 10 hours. The reaction mixture was cooled, filtered and the filtrate was evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2/CH3OH 95/5). The pure fractions were collected and the solvent was evaporated, yielding 22.5 g (72%) of 4-(3,4-dichlorophenyl)-1-piperazinepentanenitrile (interm. 2).

来源