反应 #2045020

反应方程式

4-Nitro phenol

K2CO3

methyl chloroacetate

→

31

收率 72.5%

Methyl(4-Nitro phenoxy)acetate

收率 72.5%

溶剂

acetone

反应条件

后处理

1. 1
   温度refluxed for 12 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (1500 ml) added
4. 4
   过滤Crude 31 was filtered
5. 5
   其他dried
6. 6
   其他recrystallised from a mixture of ethyl acetate:hexane (1:5)

实验过程

To a mixture of 4-Nitro phenol (100 g, 719 mmol) and anhydrous K2CO3 (400 g, 2.894 moles) in anhydrous acetone (950 ml) was added methyl chloroacetate (114 g, 1.050 moles) and refluxed for 12 hours. Acetone was distilled off and water (1500 ml) added. Crude 31 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 31 (110 g, 72.5%) as a white fluffy powder. M.p: 97-98.4° C.

来源