反应 #2045018

反应方程式

(4-Isocyanato-phenoxy)-acetic acid methyl ester

ethylene glycol

→

29

收率 82.9%

[4-(2-Hydroxy-ethoxycarbonylamino)-phenoxy]-acetic acid methyl ester

收率 82.9%

溶剂

Water

反应条件

后处理

1. 1
   过滤crude 29 was filtered
2. 2
   其他dried
3. 3
   其他purified by column chromatography on silica gel

实验过程

(4-Isocyanato-phenoxy)-acetic acid methyl ester 28 (15 g, 72.46 mmol) was added to ethylene glycol (30 ml) at room temperature. The reaction was exothermic and the temperature raised to 42° C. Later the reaction mixture was stirred at room temperature for 16 hours. Water (100 ml) was added and crude 29 was filtered, dried and purified by column chromatography on silica gel using chloroform as eluant to get pure 29 (16.17 g, 82.9%) as a off-white powder. M.p: 85.5-87.5° C.

来源