反应 #2045004

反应方程式

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

hydrochloric acid

→

14

收率 77.6%

(4-Amino-phenoxy)acetic acid HCl

收率 77.6%

反应条件

后处理

1. 1
   workup.DISTILLATIONExcess concentrated hydrochloric acid was distilled off in vacuum
2. 2
   过滤filtered hot
3. 3
   过滤filtered
4. 4
   其他dried

实验过程

A mixture (4-Acetylamino-phenoxy)-acetic acid ethyl ester 13 (375 g, 1.582 mmol), in concentrated hydrochloric acid (9.36 liters) was refluxed for 12 hours. Excess concentrated hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 14 (250 g, 77.6%) as a wheat colored powder. The melting point was found to be 224-226° C. The structure was confirmed with NMR.

来源