反应 #2045003

反应方程式

Paracetamol

K2CO3

ethyl bromoacetate

→

13

收率 80.1%

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

收率 80.1%

溶剂

acetone

反应条件

后处理

1. 1
   温度refluxed for 16 hours
2. 2
   workup.DISTILLATIONAcetone was distilled off
3. 3
   workup.ADDITIONwater (5 liter) was added
4. 4
   过滤Crude 13 was filtered
5. 5
   其他dried
6. 6
   其他recrystallised from a mixture of toluene:hexane (1:5)

实验过程

To a mixture of Paracetamol (300 g, 1.984 mol), and anhydrous K2CO3 (1.80 Kg, 7.814 mmol) in anhydrous acetone (3 liters) was added ethyl bromoacetate (452 gr, 2.7 mol) and refluxed for 16 hours. Acetone was distilled off and water (5 liter) was added. Crude 13 was filtered, dried and recrystallised from a mixture of toluene:hexane (1:5) to give pure 13 (377 g, 80%) as a white shining powder. The melting point was found to be 104.2-106.2° C.

来源