反应 #2044997

反应方程式

sulphuric acid

2-(6-Hydroxynaphthalen-2-yl)-propionic acid

2-(6-Hydroxynaphthalen-2-yl)propionic acid

methanol

→

6

收率 89.5%

2-(6-Hydroxynaphthalen-2-yl)-propionic acid methyl ester

收率 89.5%

反应条件

后处理

1. 1
   温度refluxed for 6 hours
2. 2
   workup.DISTILLATIONMethanol (1000 ml) was distilled off
3. 3
   其他the cooled reaction mass
4. 4
   workup.ADDITIONwas poured onto ice water (3000 ml)
5. 5
   过滤Crude 6 was filtered
6. 6
   其他dried
7. 7
   其他recrystallised from a mixture of ethyl acetate:hexane (1:5)

实验过程

To a solution of methanol (2100 ml) and sulphuric acid (84 ml) was added 2-(6-Hydroxynaphthalen-2-yl)-propionic acid 5 (420 g, 1.944 mmol), and refluxed for 6 hours. Methanol (1000 ml) was distilled off and the cooled reaction mass was poured onto ice water (3000 ml). Crude 6 was filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:5) to give pure 6 (400 g, 89.5%) as a white fluffy powder. The melting point found to be 89.5-92° C. The structure was confirmed with IR and NMR.

来源