反应 #2025285

反应方程式

hydrochloric acid

acetic acid

4-phenyl-2-butanol

toluene

→

2-acetoxy-4-phenylbutane

收率 98.5%

溶剂

pyridine

反应条件

后处理

1. 1
   workup.ADDITIONwere charged
2. 2
   其他to react them for 4 hours
3. 3
   温度while temperature being maintained at 40°-50° C
4. 4
   其他After completion of the reaction
5. 5
   萃取extracted
6. 6
   洗涤an organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate solution and water in the order
7. 7
   浓缩The thus-obtained organic layer was concentrated under a reduced pressure

实验过程

Into a four-necked flask provided with a thermometer and a stirrer, 150 g (1 mol) of 4-phenyl-2-butanol (XXX-35), 500 ml of toluene and 200 ml of pyridine were charged. 122.4 g (1.2 mol) of anhydrous acetic acid and 1 g of 4-dimethylaminopyridine were further added thereto to react them for 4 hours, while temperature being maintained at 40°-50° C. After completion of the reaction, the reaction mixture was poured into 500 ml of 4N hydrochloric acid solution, extracted and fractionated, and then an organic layer was washed with 1N hydrochloric acid, water, 5% sodium bicarbonate solution and water in the order. The thus-obtained organic layer was concentrated under a reduced pressure to obtain 189 g of 2-acetoxy-4-phenylbutane (XXIX-35) with yield of 98.5%.

来源