反应 #2021478

反应方程式

sodium acetate

2-(N-ethylanilino)ethyl acetate

phosphoryl chloride

→

2-(ethyl(4-formylphenyl)amino)ethyl acetate

收率 84.2%

溶剂

dimethylformamide

dimethylformamide

反应条件

后处理

1. 1
   其他to react for 6 hours at room temperature
2. 2
   萃取An organic layer was extracted with ethyl acetate

实验过程

After adding 55.8 g of ice-cooled phosphoryl chloride to 26.6 g of dimethylformamide, a solution of 63.0 g of the 2-(N-ethylanilino)ethyl acetate in 40 ml of dimethylformamide was slowly added at room temperature, this was caused to react for 6 hours at room temperature while stirring, and then poured into an aqueous solution of 150 g of sodium acetate under ice cooling. An organic layer was extracted with ethyl acetate and the solvent was boiled off under reduced pressure. This was refined by silica gel column chromatography to yield 60.2 g of 2-(ethyl(4-formylphenyl)amino)ethyl acetate.

来源