反应 #2016

ord-e392efa1dd0c43839d8e3026d6f4b2ee

反应方程式

N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1
D-tryptophan benzyl ester
CC(C)(CC(=O)O)NC(=O)OC(C)(C)C
3-t-butoxycarbonylamino-3-methylbutanoic acid
→
CC(C)(CC(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1)NC(=O)OC(C)(C)C
(R)-α-[(3-t-Butoxycarbonylamino-3-methyl-1-oxobutyl)amino]-1-H-indole-3-propanoic acid benzyl ester

反应物

N[C@H](Cc1c[nH]c2ccccc12)C(=O)OCc1ccccc1
D-tryptophan benzyl ester
CC(C)(CC(=O)O)NC(=O)OC(C)(C)C
3-t-butoxycarbonylamino-3-methylbutanoic acid

试剂

无

反应条件

详细条件
See reaction.notes.procedure_details.

实验过程

Prepared from D-tryptophan benzyl ester (1 g; 3.40 mmol) and 3-t-butoxycarbonylamino-3-methylbutanoic acid (0.91 g; 4.19 mmol) by the procedure described in Example 6, Step C. The yield was 0.981 g (58%).

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US05726319uspto-grants-1998_03