反应 #2006423

反应方程式

4-vinyl-benzoic acid

benzenethiol

VAZO

→

white solid

收率 85.0%

4-(2-Thiophenyl)-ethyl Benzoic Acid

收率 85.0%

溶剂

benzene

反应条件

后处理

1. 1
   其他According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask
2. 2
   温度at reflux
3. 3
   其他the solvent was evaporated under vacuo
4. 4
   其他The solid was purified by trituration

实验过程

According to the published procedure (Gareau et al., Tet. Lett., 1994, 1837), under nitrogen atmosphere in a 50 mL round bottomed flask containing 4-vinyl-benzoic acid (1.0 g, 6.75 mmoles) in 10 mL of benzene (0.7 M) was added benzenethiol (797 μL, 7.76 mmoles) followed by VAZO™ (Aldrich Chemical Company, 495 mg, 2.02 mmoles). The mixture was stirred for 12 hours at reflux. The resulting solution was cooled at room temperature and the solvent was evaporated under vacuo. The solid was purified by trituration using hexane and dichloromethane to afford 1.94 g (85%) of white solid.

来源