反应 #2006420

反应方程式

Allylbenzene

4-bromobenzoic acid

Et3N

triphenylphosphine

→

mixture

收率 19.9%

4(3-Phenylpropenyl)-benzoic Acid 4-(3-Phenyl-2-propenyl)-benzoic Acid

收率 19.9%

溶剂

acetonitrile

反应条件

后处理

1. 1
   温度at reflux overnight in a round bottom flask
2. 2
   萃取Added HCl 1N, extracted with EtOAc
3. 3
   干燥dried the organic layer on anhydrous MgSO4
4. 4
   过滤filtered
5. 5
   其他evaporated solvent under vacuum
6. 6
   其他Purified by column chromatography

实验过程

Allylbenzene (255 μL, 1.9 mmol), 4-bromobenzoic acid (523 mg, 2.6 mmol), Et3N (0.91 mL, 6.5 mmol), Palladium (II) Acetate (16 mg, 0.052 mmol), triphenylphosphine (60 mg, 0.21 mmol) and acetonitrile (5 mL) were stirred at reflux overnight in a round bottom flask. Added HCl 1N, extracted with EtOAc, dried the organic layer on anhydrous MgSO4, filtered, evaporated solvent under vacuum. Purified by column chromatography using 10% MeOH/CH2Cl2 yielded 90 mg (14%) of mixture of two regioisomers 54. The mixture was then submitted for hydrogenation without further characterization.

来源