反应 #2006419

反应方程式

HCl

methyl ester

Methyl-4-(3-oxo-3-phenylpropyl)-benzoate

LiOH

→

title compound

4-(3-oxo-3-Phenylpropyl)-benzoic Acid

溶剂

water THF

反应条件

后处理

1. 1
   萃取the solution was extracted with EtOAc
2. 2
   干燥the organic layer was dried over anhydrous MgSO4
3. 3
   过滤Filtration and evaporation of the solvent under vacuum
4. 4
   其他followed by purification by column chromatography

实验过程

To a solution of methyl ester 47 (195 mg, 0.73 mmol) in water/THF (1:1, 0.07M) was added LiOH (46 mg, 1.1 mmol). The resulting solution was stirred overnight at room temperature or until no starting material was detected by TLC. HCl 1N was added and the solution was extracted with EtOAc and the organic layer was dried over anhydrous MgSO4. Filtration and evaporation of the solvent under vacuum followed by purification by column chromatography using 10% MeOH/CH2Cl2, gave the title compound.

来源