反应 #2006416

反应方程式

Sodium methoxide

4-carboxybenzaldehyde

acetophenone

→

43

收率 72.0%

4-(3-oxo-3-Phenylpropenyl)-benzoic Acid

收率 72.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他half of the volume of methanol was removed under reduced pressure
2. 2
   workup.ADDITIONThe mixture was poured into HCl 1M (50 mL) (until pH=2) and ethyl acetate
3. 3
   workup.ADDITIONwas added
4. 4
   萃取The separated aqueous layer was extracted with ethyl acetate (3×30 mL)
5. 5
   干燥dried (MgSO4 anh.)
6. 6
   过滤filtered
7. 7
   其他evaporated
8. 8
   其他The residue was triturated with dichloromethane-hexanes (1:1)

实验过程

Sodium methoxide (1.8 g, 33.3 mmol) was added to a stirred suspension of 4-carboxybenzaldehyde (2.5 g, 16.6 mmol) and acetophenone (2.0 g uL, 16.6 mmol) in methanol (50 mL) at room temperature. The mixture was stirred at room temperature for 16 hours, and half of the volume of methanol was removed under reduced pressure. The mixture was poured into HCl 1M (50 mL) (until pH=2) and ethyl acetate was added. The separated aqueous layer was extracted with ethyl acetate (3×30 mL) dried (MgSO4 anh.), filtered and evaporated. The residue was triturated with dichloromethane-hexanes (1:1) to afford 3 g of 43 (72% yield).

来源