反应 #2006410

反应方程式

4-aminophenylacetic acid

HCl

methanol

→

3

收率 74.0%

Methyl-4-aminophenylacetate

收率 74.0%

反应条件

后处理

1. 1
   其他The reaction mixture was then quenched with a saturated aqueous solution of NaHCO3
2. 2
   其他The methanol was evaporated under reduced pressure
3. 3
   萃取the aqueous layer was extracted several times with AcOEt
4. 4
   干燥The combined organic extracts were dried over (MgSO4)
5. 5
   其他evaporated
6. 6
   其他The crude residue was purified by flash chromatography

实验过程

To a solution of 4-aminophenylacetic acid (10 g, 66.2 mmol) in methanol (150 mL) at room temperature was added HCl conc. (37% 25 mL). The mixture became yellow and was stirred overnight. The reaction mixture was then quenched with a saturated aqueous solution of NaHCO3. The methanol was evaporated under reduced pressure and the aqueous layer was extracted several times with AcOEt. The combined organic extracts were dried over (MgSO4) and evaporated. The crude residue was purified by flash chromatography using hexane/AcOEt (4:1) as solvent mixture yielding 3 as a yellow oil (9.44 g, 74%).

来源