反应 #2006409

反应方程式

NaHCO3

3-aminophenylacetic acid

HCl

→

1

收率 79.0%

Methyl-3-aminophenylacetate

收率 79.0%

溶剂

methanol

反应条件

后处理

1. 1
   其他The solvent was removed under reduced pressure
2. 2
   萃取the aqueous phase was extracted several times with CH2Cl2
3. 3
   干燥The combined organic extracts were dried over (MgSO4)
4. 4
   其他evaporated
5. 5
   其他The crude mixture was purified by flash chromatography

实验过程

To a solution of 3-aminophenylacetic acid (3 g, 19.85 mmol) in methanol (50 mL) at room temperature was added HCl conc. (37%, 7.5 mL). The mixture was stirred 6 h at room temperature then treated with a saturated aqueous solution of NaHCO3. The solvent was removed under reduced pressure then the aqueous phase was extracted several times with CH2Cl2. The combined organic extracts were dried over (MgSO4) and evaporated. The crude mixture was purified by flash chromatography using hexane/AcOEt (1:1) yielding 1 as a yellow oil (3.06 g, 79%).

来源